https://en.wikipedia.org/wiki/Saponin
"Most saponins, which readily dissolve in water, are poisonous to fish.[11]
Therefore, in ethnobotany, they are primarily known for their use by indigenous people in obtaining aquatic food sources. Since prehistoric times, cultures throughout the world have used fish-killing plants, mostly those containing saponins, for fishing.[12][13]
Although prohibited by law, fish-poison plants are still widely used by indigenous tribes in Guyana.[14]
On the Indian subcontinent, the Gondi people are known for their use of poison-plant extracts in fishing.[15]
Many of California's Native American tribes traditionally used soaproot, (genus Chlorogalum) and/or the root of various yucca species, which contain saponin, as a fish poison.
They would pulverize the roots, mixing in water to create a foam, and then add the suds to a stream.
This would kill, or incapacitate, the fish, which could be gathered easily from the surface of the water. Among the tribes using this technique were the Lassik, the Luiseño, and the Mattole."
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"The amphipathic nature of saponins gives them activity as surfactants with potential ability to interact with cell membrane components, such as cholesterol and phospholipids, possibly making saponins useful for development of cosmetics and drugs.[17]
Saponins have also been used as adjuvants in development of vaccines,[18] such as Quil A, an extract from the bark of Quillaja saponaria.[17][19]
This makes them of interest for possible use in subunit vaccines and vaccines directed against intracellular pathogens.[18] In their use as adjuvants for manufacturing vaccines, toxicity associated with sterol complexation remains a concern.[20]
While saponins are promoted commercially as dietary supplements and are used in traditional medicine, there is no high-quality clinical evidence that they have any beneficial effect on human health.[19] Quillaja is toxic when consumed in large amounts, involving possible liver damage, gastric pain, diarrhea, or other adverse effects.[19]
The plant Çöven, Gypsophila simonii is widely distributed throughout Çankırı, where it is a native species, and Turkey. In this study, chemical and physical properties of unripe saponins obtained by extraction from the roots of Gypsophila simonii, an endemic plant, were isolated and investigated. Purified aglycones recovered from acid hydrolysis of the saponins were separated by reversed chromatography on a thin layer of silica gel. Phytochemical tests showed the presence of terpenoids in the crude extracts.[21][22]
Saponins are used for their effects on ammonia emissions in animal feeding.[23]
Dioscin, the saponin from Dioscorea spp. remains an important source for diosgenin, which is then utilized in the semi-synthetic or biosynthetic production of progesterone and corticosteroids."
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"Froth Test
Uses plant Gogo (bark) Entada phaseoloides as control. The positive result shows a honeycomb froth that is higher than 2 cm that persists for 10 minutes or longer.
Blood Agar Media (BAM): Is an agar cup semi-quantitative method that shows positive result of hemolytic halos.[10]
Role in plant ecology and impact on animal foraging
In plants, saponins may serve as anti-feedants,[2][4] and to protect the plant against microbes and fungi.[citation needed] Some plant saponins (e.g. from oat and spinach) may enhance nutrient absorption and aid in animal digestion.
However, saponins are often bitter to taste, and so can reduce plant palatability (e.g., in livestock feeds), or even imbue them with life-threatening animal toxicity.[4] Some saponins are toxic to cold-blooded organisms and insects at particular concentrations.[4]
Further research is needed to define the roles of these natural products in their host organisms, which have been described as "poorly understood" to date"
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"Saponins have historically been understood to be plant-derived, but they have also been isolated from marine organisms such as sea cucumber.[1][5] Saponins are indeed found in many plants,[1][6] and derive their name from the soapwort plant (genus Saponaria, family Caryophyllaceae), the root of which was used historically as a soap.[2]
Saponins are also found in the botanical family Sapindaceae, including its defining genus Sapindus (soapberry or soapnut) and the horse chestnut, and in the closely related families Aceraceae (maples) and Hippocastanaceae). It is also found heavily in Gynostemma pentaphyllum (Gynostemma, Cucurbitaceae) in a form called gypenosides, and ginseng or red ginseng (Panax, Araliaceae) in a form called ginsenosides.
Saponins are also found in the unripe fruit of Manilkara zapota (also known as sapodillas), resulting in highly astringent properties. Within these families, this class of chemical compounds is found in various parts of the plant: leaves, stems, roots, bulbs, blossom and fruit.[7]
Commercial formulations of plant-derived saponins, e.g., from the soap bark (or soapbark) tree, Quillaja saponaria, and those from other sources are available via controlled manufacturing processes, which make them of use as chemical and biomedical reagents.[8] In China, the rhizomes (tubers) of Dioscorea zingiberensis C.H. Wright also produces steroidal saponins (TSS) as part of a treatment for cardiovascular disease"
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https://en.wikipedia.org/wiki/Saponin
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